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32-34 Acute toxicities arise from sudden exposures to substantial quantities of some metals (such as from occupational exposure to aluminum dust or breaking a mercury-containing thermometer) and typically affect multiple organ systems, commonly the gastrointestinal tract, cardiovascular system, nervous system, endocrine system, kidneys, hair, and nails

Because of that, the NICE recommendations lean towards individualised care: tailoring the dose, frequency and delivery method, following people up at around three months, and reviewing sooner if symptoms are severe or if someone is pregnant or breastfeeding

For a complex joint like the shoulder, this means targeting the general area

Without a bacteriostatic agent, any bacteria introduced during needle insertion could multiply rapidly in the nutrient-free but habitable aqueous environment, potentially reaching levels that could compromise experimental results or in the case of cell culture work contaminate entire experimental setups